Pyrethroid-induced Biochemical Changes and Properties of Human Platelet Membrane

Authors: Narendra Maddu

Country: India

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Abstract: The effect of allethrin and prallethrin based mosquito repellent pyrethroids on human platelet membrane, membrane cholesterol, phospholipids, lipid peroxidation in platelet membrane were investigated. Humans were chronically exposed to 7-10 years continuously for 8-10 hours per day by inhalation of these compounds exposure enter into circulation and changes in platelet membranes. Platelet membrane fluidity was determined by DPH and pyrene fluorescence anisotropy experiments show that allethrin and prallethrin exposed subjects, compared with controls, induced a significant decrease in platelet membrane fluidity measured by DPH and pyrene. A significant increase in the lipid peroxidation both exposed subjects. A significant decrease in the activity of platelet membrane-bound enzymes, the activity of total ATPase, Na+/K+-ATPase activity and Ca2+-dependent ATPase activity and Mg2+-ATPase are respectively.

Keywords: Pyrethroids, Platelet Membrane, ATPases, Membrane Fluidity, Allethrin, Prallethrin, Lipid Peroxidation

Paper Id: 1679

Published On: 2013-09-25

Published In: Volume 1, Issue 1, September-October 2013

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