The Impact of Pre-analytical Variables on the Accuracy of Biochemical Tests: A Hospital-Based Study on Sample Handling, Storage, and Timing

Authors: Kholoud H. Aldubayan, Amal M. Hariri, Ali S. Alamri, Mshary A. Aldraihim, Manal Y. Gattan

DOI: https://doi.org/10.5281/zenodo.13627584

Short DOI: https://doi.org/gt88b6

Country: Saudi Arabia

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Abstract: The accuracy of biochemical tests in clinical laboratories is highly influenced by pre-analytical variables, including sample handling, storage conditions, and timing. This study aimed to investigate the impact of these factors on the accuracy of glucose, potassium, lactate dehydrogenase (LDH), and alanine transaminase (ALT) test results in a hospital setting. A total of 500 blood samples were analyzed to assess the effects of improper handling (e.g., hemolysis), prolonged storage, and delays in processing. The findings revealed that improper sample handling significantly elevated potassium and LDH levels, while glucose and enzyme levels degraded with prolonged storage at room temperature. Additionally, delays in processing resulted in lower glucose and higher potassium levels, emphasizing the importance of timely sample processing. These results underscore the need for strict adherence to pre-analytical protocols to ensure accurate test results and enhance patient care.

Keywords: Pre-analytical variables, biochemical test accuracy, sample handling, storage conditions, processing delays, hemolysis, clinical laboratory

Paper Id: 231103

Published On: 2020-02-03

Published In: Volume 8, Issue 1, January-February 2020

Cite This: The Impact of Pre-analytical Variables on the Accuracy of Biochemical Tests: A Hospital-Based Study on Sample Handling, Storage, and Timing - Kholoud H. Aldubayan, Amal M. Hariri, Ali S. Alamri, Mshary A. Aldraihim, Manal Y. Gattan - IJIRMPS Volume 8, Issue 1, January-February 2020. DOI 10.5281/zenodo.13627584

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