Evaluating the Impact of Iron Supplementation on Hemoglobin Recovery in Frequent Blood Donors: A Randomized Controlled Trial

Authors: Abdulaziz M. Alangari, Abdullah M. Alenazi, Dima A. Alharbi, Sarah A. Alanazi, Hanan T. AlAnazi, Bushra M. Alshammari

DOI: https://doi.org/10.5281/zenodo.13846201

Short DOI: https://doi.org/g5vww3

Country: Saudi Arabia

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Abstract: Background: Frequent blood donors are at risk of hemoglobin and iron depletion, leading to deferrals and prolonged recovery times. This randomized controlled trial aimed to evaluate the efficacy of iron supplementation in promoting faster hemoglobin recovery and improving iron stores in frequent blood donors.

Methods: A total of 200 frequent donors were randomized into two groups: the iron supplementation group (n=100) received 37.5 mg of oral iron daily for 6 weeks, while the control group (n=100) received a placebo. Hemoglobin and ferritin levels were measured at baseline, 2 weeks, 4 weeks, and 6 weeks post-donation.

Results: The iron supplementation group showed significantly faster hemoglobin recovery (90% vs. 65% returned to baseline at 6 weeks, p < 0.001). Ferritin levels increased by 21.8% in the supplementation group, while the control group experienced a 7.2% decrease (p < 0.001). A higher proportion of the iron supplementation group was eligible for future donations at 6 weeks (90% vs. 65%, p < 0.001).

Conclusion: Iron supplementation significantly enhances hemoglobin recovery and increases iron stores in frequent blood donors, reducing deferral rates and improving donor retention.

Keywords: Iron supplementation, Hemoglobin recovery, Blood donation, Frequent donors, Iron deficiency, Randomized controlled trial

Paper Id: 231253

Published On: 2015-08-11

Published In: Volume 3, Issue 4, July-August 2015

Cite This: Evaluating the Impact of Iron Supplementation on Hemoglobin Recovery in Frequent Blood Donors: A Randomized Controlled Trial - Abdulaziz M. Alangari, Abdullah M. Alenazi, Dima A. Alharbi, Sarah A. Alanazi, Hanan T. AlAnazi, Bushra M. Alshammari - IJIRMPS Volume 3, Issue 4, July-August 2015. DOI 10.5281/zenodo.13846201

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