Formulation and Evaluation of Anti-Inflammatory Cream

Authors: Shinde Shubhangi Bhausaheb, Garje Supriya Balau, Prof. Veer Sujata Umakant, Prof. Garud Neha Sunil

Country: India

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Abstract: This study was performed to develop a topical cream of Diclofenac-Na which has potent anti-inflammatory activity by oral administration. At first, research was carried out on the cream base which influences the external anti-inflammatory effect of the drug. Cream of Diclofenec-Na were prepared with base of Bee-wax and Clove oil. The cream was found to have potent effect. Therefore, in next, an optimum concentration of diclofenac –Na in cream was determined comparing the anti-inflammatory effect. Diclofenac sodium cream is a topical NSAID used to manage pain and inflammation associated with conditions like osteoarthritis and actinic keratosis. It works by reducing the production of prostaglandins, which are chemical messengers that cause pain, swelling, and inflammation. Diclofenac cream is generally well-tolerated, with mild side effects primarily localized to the application site, such as redness, itching, or rash. Diclofenac is used to treat pain and other symptoms of arthritis of the joints (eg, osteoarthritis), such as inflammation, swelling, stiffness, and joint pain. Topical diclofenac sodium cream is a nonsteroidal anti-inflammatory drug (NSAID) formulation designed for local application to relieve pain and inflammation associated with osteoarthritis. This cream formulation has been shown to provide significant pain relief and improve physical function in patients with osteoarthritis, with a favorable safety profile characterized by minimal systemic absorption and low incidence of gastrointestinal adverse events. Clinical trials have demonstrated the efficacy and safety of diclofenac sodium cream in managing osteoarthritis symptoms, making it a valuable treatment option for patients seeking localized pain relief. [1,2,3]

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Paper Id: 232524

Published On: 2025-05-31

Published In: Volume 13, Issue 3, May-June 2025

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