Formulation and Evaluation of Semi-Synthetic Gel Containing Tagetes Erecta and Curcumin Extract for the Treatment of Atopic Dermatitis (Eczema)

Authors: Miss. Anuradha Sanjay Gatane, Asst. Prof. Miss. Sujata Umakant, Asst. Prof. Miss. Neha Sunil Garud

Country: India

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Abstract: Atopic dermatitis is a chronic inflammatory skin condition characterized by dry, itchy and inflamed skin, significantly impacting the quality of life of affected individuals. Current treatments often involve topical corticosteroids, immunomodulators and moisturizers but these may have limitations such as side effects, limited efficacy.This study aimed to formulate and evaluate a semi- synthetic gel formulation integrating natural phytochemicals from Tageteserecta(commonlyknown as marigold) and Curcumin- to botanicals known for their anti-inflammatory, antioxidant and wound healing properties.
The objective of this study was to formulate, optimize and evaluate a semi-synthetic gel incorporating extracts from Tagetes erecta and curcumin for potential therapeutic application in the management of atopic dermatitis. The gel was formulated using a combination of natural and synthetic polymers, including carbapol and triethanolamine and evaluated for its physical, chemical and microbiological properties. The gel showed good spreadability, pH and viscosity and was found to be stable under various storge conditions. In vitro studies demonstrated the gel’s anti-inflammatory and antioxidant properties and its ability to reduce inflammation and oxidative stress. The anti-inflammatory effects of gel were attributed to the presence of flavonoids and carotenoids in Tageteserecta and Curcumin, which inhibited the production of pro-inflammatory cytokines and enzymes. The antioxidant properties of a gel were also attributed to the presence of these bioactive compounds, which neutralized free radicals and reduced oxidative stress.
The results suggest that the semi-synthetic gel containing Tagetes erecta and Curcumin extracts may be a promising treatment option for atopic dermatitis, offering a natural and effective alternatives to conventional treatments. The gel’s stability, spreadability and anti-inflammatory and anti-oxidant properties make it an attractive option for topical application.

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Paper Id: 232531

Published On: 2025-05-31

Published In: Volume 13, Issue 3, May-June 2025

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