The drug loaded carrier systems of nonsteroidal anti inflammatory medication mefenamic acid and indomethacin

Authors: Bhavesh Sen, Firoz Khan, Kailash Kumar Pathak, Nida Khan, Deepak Verma

Country: India

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Abstract: The drug loaded carrier systems of nonsteroidal anti inflammatory drug mefenamic acid and indomethacin were prepared and further incorporated in transdermal gel formulation. The formulation of liposome and transferosomes were optimized based on drug entrapment efficiency and in-vitro drug permeation.
The optimized formula of liposome contained phospholipid 109.9 mg (0.14 mM) and cholesterol 27.68 mg (0.071 mM) along with 100 mg (0.28 mM) mefenamic acid, whereas the optimized formula of transferosomes contained phospholipid 91.41 mg (0.12 mM), surfactant 24 mg (0.06 mM) and cholesterol 34.60 mg (0.09 mM) in formulation with 100 mg (0.28 mM) mefenamic acid.

Keywords: Mefenamic Acid, Indomethacin, Transdermal Gel

Paper Id: 232845

Published On: 2025-12-06

Published In: Volume 13, Issue 6, November-December 2025

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