To develop and evaluate floating tablets containing a model anti-ulcer herbal drug for the treatment of peptic ulcers

Authors: Rahul Mewada, Firoz Khan, Kailash Kumar Pathak, Nida Khan, Deepak Verma

Country: India

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Abstract: Floating tablets containing Azadirachta indica bark extract were successfully formulated using HPMC K100M, Chitosan, sodium bicarbonate, talc, and magnesium stearate. All tablets exhibited favorable physical, chemical, and mechanical properties, with formulation F2 showing the most promising results in terms of floating behavior, swelling, and sustained drug release.In vitro dissolution testing in 0.1 N HCl (pH 1.2) at 37°C showed drug release between 93% and 96% within 12 hours. The formulation demonstrated significant gastroretentive potential, which may improve oral bioavailability and therapeutic efficacy.The safety profile and anti-ulcer activity of the A. indica bark extract-based floating tablets were validated in animal studies. Hence, these floating tablets could serve as a promising alternative dosage form for the treatment of peptic ulcer disease, combining the advantages of herbal medicine with modern controlled-release technology.

Keywords: Azadirachta indica, Peptic ulcer

Paper Id: 232847

Published On: 2025-12-06

Published In: Volume 13, Issue 6, November-December 2025

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