Development and Validation of a Green UV–Spectrophotometric Method for the Estimation of Olmesartan Medoxomil Using Eco-Friendly Solvents

Authors: Sandeep Kumar Nagar, Ritesh Agrawal, Udit Narain Soni

Country: India

Full-text Research PDF File:   View   |   Download

Abstract: The present study successfully established a validated UV spectrophotometric analytical method for the estimation of OlmesartanMedoxomil in bulk drug and marketed tablet formulations. The method was developed using a simple solvent system and optimized analytical conditions, ensuring ease of operation and reproducibility.
Validation of the method as per ICH guidelines confirmed that the method is linear, accurate, precise, robust, and selective. The assay results of marketed formulations demonstrated that the developed method can reliably estimate the drug content without interference from formulation excipients.
Statistical evaluation of validation parameters showed %RSD values well within acceptable limits, indicating high precision and reliability of the method. The robustness study further confirmed that minor variations in experimental conditions do not affect analytical performance.
In conclusion, the developed UV spectrophotometric method is economical, rapid, and suitable for routine quality control analysis of OlmesartanMedoxomil in pharmaceutical industries, academic laboratories, and regulatory environments. The method can be confidently applied for batch-to-batch quality assessment of tablet formulations containing OlmesartanMedoxomil

Keywords: High performance liquid chromatography (HPLC) ,olmesartan medoxomil (OM), ultra high-performance liquid chromatography (UPLC), UV spectroscopy.

Paper Id: 232893

Published On: 2026-01-17

Published In: Volume 14, Issue 1, January-February 2026

Share this