Formulation Development and Evaluation of Floating Tablet Of Ondansetron Hydrochloride In Combination With Ranitidine Hydrochloride

Authors: Abhishek Rathore, Nida Faheem, Kailash Kumar Pathak

Country: India

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Abstract: Gastroretention helps to provide better availability of new products with suitable therapeutic activity and substantial benefits for patients. This mode of administration would best achieve the known pharmacokinetic and pharmacodynamic advantages of CR- DFs of these drugs. The need for gastroretentive dosage forms (GRDFs) has led to extensive efforts in both academia and industry towards the development of such drug delivery systems. These efforts resulted in GRDFs that were designed, in large part, based on the following approaches. Ranitidine is given in combination with ondansetron.In women with heartburn/acid reflux and nausea/vomiting of pregnancy, an observational study found that acid-reducing pharmacotherapy (e.g. antacids, H2 blockers, proton pump inhibitors) combined with anti-emetic therapy resulted in significant improvement in symptoms and well-being three to four days after beginning therapy. The aim of the present study is to prepare fine floating tablets of the combination of the two and investigate the possibility of those tablets as a delivery system for controlled release of ondansetron and immediate release of ranitidine.

Keywords: HPMC K 30, PVP K30, Floating drug delivery system, Gastro retentive drug delivery system, Combination, Floating lag time.

Paper Id: 232894

Published On: 2026-01-17

Published In: Volume 14, Issue 1, January-February 2026

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