International Journal of Innovative Research in Engineering & Multidisciplinary Physical Sciences
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Comparison of Topological, Physiochemical and Hydrophobic Parameters for QSAR Study on Flavonoid Derivatives as Tyrosins Kinase Inhibitors

Authors: Kapil Tiwari, Pramod K Saxena, Brij K Tiwari

DOI: 10.17605/OSF.IO/WTESNShort DOI: ggrs99

Country: India View / Download Full Text PDF File


Abstract: QSAR studies on a large set of fiavonoids derivatives as tyrosine kinase inhibitators have been preformed using 3D-topological,physiological parameters. Activity analysed in the present study in the log1/(inverse logarithmic value of 50% inhibitory concentration).The tyrosine kinase inhibition activity is usually expressed in terms of inverse logarithmic concentration.The set of 104 fiavonoid derivatives is divided in three different sets based on nature of substitution types of substitution and activity shown by the compounds.

Keywords: Cytotoxic concentration,QSAR,Multiple linear regression


Paper Id: 439

Published On: 2018-12-28

Published In: Volume 6, Issue 6, November-December 2018

Cite This: Comparison of Topological, Physiochemical and Hydrophobic Parameters for QSAR Study on Flavonoid Derivatives as Tyrosins Kinase Inhibitors - Kapil Tiwari, Pramod K Saxena, Brij K Tiwari - IJIRMPS Volume 6, Issue 6, November-December 2018. DOI 10.17605/OSF.IO/WTESN

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