Modeling and 3D QSAR Study of TIBO Derivatives as Potent Reverse Transcriptase Inhibitors
Authors: Brij K Tiwari, Kapil Tiwari, Pramod K Saxena, Ashish Kumar
Country: India View / Download Full Text PDF File
Abstract: In the present work,a quantitative structure activity study has been performed a develop mathematical relationship between structural descriptor and biological activity log1/c (cytoctoxic concentration)of 19 TIBO derivatives with the help of Hyperchem7 software,ACD Chemsketch. Non-conventional physciochemical properties used in present study are calculating using Hyperchem7 software.All classical physicochemical descriptor are calculated using ACD Chemsketch software and the multiple regression analysis is carried out for obtaining QSAR model. The objective of the work is to obtain more information about the structural requirements underlying the cytotoxicity of inhibitors of NNRT-1.On the basis of the result obtained we model the compound having predictive potential.
Keywords: cytotoxicconcentration,NNRTI-1,physicochemical descriptors.
Paper Id: 442
Published On: 2018-12-03
Published In: Volume 6, Issue 6, November-December 2018
Cite This: Modeling and 3D QSAR Study of TIBO Derivatives as Potent Reverse Transcriptase Inhibitors - Brij K Tiwari, Kapil Tiwari, Pramod K Saxena, Ashish Kumar - IJIRMPS Volume 6, Issue 6, November-December 2018. DOI 10.17605/OSF.IO/J2F3S