International Journal of Innovative Research in Engineering & Multidisciplinary Physical Sciences
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Synthesis and Spectral Studies of 1,5-benzodiazepines Derivatives from β-diketones/β-ketoesters

Authors: Shachi Sainger, Man Mohan Goyal, Kapil, Dev Datt Verma

DOI: https://doi.org/10.17605/OSF.IO/72VZE

Short DOI: https://doi.org/ggkv75

Country: India

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Abstract: Synthesis of 1,5-benzodiazepines derivatives was achieved by Diazotization of 7-aminocephalosporanic acid (1) with sodium nitrite in presence of mineral acid form diazonium salt (2). The resulting product (2) was treated with different β-diketones (3a-c) to form new derivatives of various β-diketones(4a-c). The derivatives of β-diketones(4a-c) are finally treated with o-phenylenediamine (o-PDA) to obtained 1,5-benzodiazepines derivatives, (5a-c). All the newly synthesized compound were characterized by elemental analysis and spectral studies.

Keywords: 1,5-benzodiazepines, mineral acids, β-diketones/β-ketoester, o-phenylenediamine (o-PDA)


Paper Id: 594

Published On: 2019-08-05

Published In: Volume 7, Issue 4, July-August 2019

Cite This: Synthesis and Spectral Studies of 1,5-benzodiazepines Derivatives from β-diketones/β-ketoesters - Shachi Sainger, Man Mohan Goyal, Kapil, Dev Datt Verma - IJIRMPS Volume 7, Issue 4, July-August 2019. DOI 10.17605/OSF.IO/72VZE

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